Searchable abstracts of presentations at key conferences in endocrinology

ea0003p141 | Endocrine Tumours and Neoplasia | BES2002

Hunting for oncogenes in pituitary adenomas - a cautionary tale of new technology

Morris D , Lillington D , Strefford J , Korbonits M , Young B , Grossman A

The proto-oncogene Gsalpha has been implicated in a significant minority of somatotrophinomas, but the search for candidate oncogenes in the remaining somatotrophinomas, and in the great majority of other types of benign pituitary adenomas, has so far been unsuccessful. Microarray-based comparative genomic hybridisation (microarray-CGH) is a novel DNA microarray technique that has been shown to identify gain or loss at the gene level, and has been proposed as a tool to screen ...